![]() baumannii have challenged clinicians and healthcare providers ( Bergogne-Berezin and Towner 1996 Bernards et al. Difficulties in containing, controlling, and eliminating the spread of A. Sequence of any microbe and, when combined with genetic screens, can identify many novel genes important for microbial pathogenesis.Īcinetobacter baumannii is a Gram-negative, nonmotile, obligate aerobic coccus that is commonly found in soil, water, and sewage, and in healthcare The DNA sequencing approach described in this study allows the rapid elucidation of the DNA baumannii and verified that six of the islands contain virulence genes, including two novel islands containing genes that lacked homology Insertional mutagenesis generated avirulent isolates of A. Type IV secretion systems have been demonstrated to be important for virulence in other organismsĪnd thus are likely to help mediate pathogenesis of A. ![]() The largest island contains elements homologous to the Legionella/Coxiella ![]() Pathogenesis, a remarkable number of the islands (16) contain genes implicated in virulence, indicating the organism devotesĪ considerable portion of its genes to pathogenesis. Putative alien islands, indicating that the genome has acquired a large amount of foreign DNA. A significant fraction of ORFs (17.2%) are located in 28 Excluding the rDNA repeats, theĪssembled genome is 3,976,746 base pairs (bp) and has 3830 ORFs. Involving high-density pyrosequencing, a novel, rapid method of high-throughput sequencing. The genome of this organism was sequenced using a strategy Using a combination of DNA sequencing and insertional mutagenesis. We explored the pathogenic content of this harmful pathogen Pneumonia, meningitis, septicemia, and urinary tract infections. Acinetobacter baumannii has emerged as an important and problematic human pathogen as it is the causative agent of several types of infections including
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